상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Heterocyclic compounds from Chrysanthemum coronarium L. and their inhibitory activity on hACAT-1, hACAT-2, and LDL-oxidation

Authors 

M C SongH J YangTae Sook JeongK T KimN I Baek

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2008

Citation 

Archives of Pharmacal Research, vol. 31, no. 5, pp. 573-578

Keywords 

5,5′-Dibuthoxy-2,2′-bifuranadenosinechrysathemum coronarium LHACATLDL-oxidationmethyl trans-ferulateprunasinpterolactamsambunigrin5,5' dibutoxy 2,2' bifuran

Abstract 

The aerial parts of Chrysanthemum coronarium L. were extracted with MeOH, and the concentrated extract was partitioned using EtOAc, n-BuOH, and H 2O, successively. Repeated column chromatography of the EtOAc and n-BuOH fractions gave a new heterocycle, 5,5′-dibuthoxy-2,2′-bifuran (1) along with five known compounds: methyl trans-ferulate (2), prunasin (3), sambunigrin (4), pterolactam (5), and adenosine (6), which were identified by several spectroscopic methods including NMR and MS. This paper is the first report on the isolation of these compounds from C. coronarium L. The IC 50 values of compound 1 for human Acyl-CoA:cholesterol acyltransferase (hACAT)-1 and hACAT-2 were 0.16 mM and 0.19 mM, respectively. Compound 2 inhibited low-density lipoprotein (LDL) oxidation with an IC 50 value of 7.7 μM.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-001-1195-4

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)