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Title 

Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor

 

Benzothiazole amide 및 urea 유도체의 합성과 Raf-1에 대한 활성평가

Authors 

Eun Young SongN KaurM Y ParkY JinKyeong LeeG KimK Y LeeJ S YangJ H ShinK Y NamK T NoG Han

Publisher 

Elsevier

Issue Date 

2008

Citation 

European Journal of Medicinal Chemistry, vol. 43, no. 7, pp. 1519-1524

Keywords 

antiproliferativebenzothiazole derivativesRaf-1 activityamide

Abstract 

A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.

ISSN 

0223-5234

Link 

http://dx.doi.org/10.1016/j.ejmech.2007.10.008

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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