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Title 

Discovery of VHR phosphatase inhibitors with micromolar activity based on structure-based virtual screening

 

구조기반 가상설계를 이용한 VHR 저해제 연구

Authors 

H ParkSuk Kyeong JungDae Gwin JeongSeong Eon RyuSeung Jun Kim

Publisher 

Wiley-VCH Verlag

Issue Date 

2008

Citation 

ChemMedChem, vol. 3, no. 6, pp. 877-880

Keywords 

dockinginhibitorssolvationVHR phosphatasevirtual screeningdual specificity phosphatase 3enzyme inhibitorchemical structuredrug screeningstructure activity relation

Abstract 

(Chemical Equation Presented) Human VHR phosphatase has been shown to be involved in the regulation of cell-cycle progression and is itself modulated during the cell cycle, indicating that VHR can serve as a therapeutic target for cancer. In the present study, we identify new VHR inhibitors by means of a structure-based drug design protocol involving the virtual screening with docking simulations and in vitro enzyme assay.

ISSN 

1860-7187

Link 

http://dx.doi.org/10.1002/cmdc.200700348

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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