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Title 

Biochemical charactrization of a glycosyltransferase homolog from an oral pathogen Fusobacterium nucleatum as a human glycan-modifying enzyme

Authors 

Seong Hun KimDoo-Byoung OhOh Suk KwonJ K JeongYun Mi LeeK KoJeong Heon KoH A Kang

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2008

Citation 

Journal of Microbiology and Biotechnology, vol. 18, no. 5, pp. 859-865

Keywords 

aceriphyllum rossiianticomplement activityclassical pathwayolean-27-carboxylic acid derivativessaxifragaceaecomplement classical pathwaymedicinal plantstructure activity relationcomplement pathway, classical

Abstract 

To provide a better understanding of the anti-complement activity of triterpenoids, seven unusual pentacyclic triterpenoids bearing a carboxyl group at C-27 were evaluated for their anti-complement activities against the classical pathway of the complement system. The triterpenoids were isolated from the whole plant of Aceriphyllum rossii of the family Saxifragaceae and were determined to be 3α,23-isopropylidenedioxyolean-12-en-27-oic acid (1), 3-oxoolean-12-en-27-oic acid (2), 3α-hydroxyolean-12-en-27-oic acid (3), β-peltoboykinolic acid (4), 3α,23-diacetoxyolean-12-en-27-oic acid (5), 23-hydroxy-3-oxoolean-12-en-27-oic acid (6) and aceriphyllic acid A (7). Among them, compounds 2, 3, and 5 showed significant anticomplement activity on the classical pathway with IC50 values of 71.4, 98.5, and 180.7 μM, respectively, whereas compounds 1, 4, 6, and 7 were inactive. Our findings suggest that both the ketone at C-3 and the methyl at C-23 in the oleanane triterpenoids with a carboxyl group at C-27 are important for the anticomplement activity against the classical pathway.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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