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Title 

Inhibitory effect on replication of enterovirus 71 of herb methanol extract

Authors 

Hwa-Jung ChoiJ H SongY J AhnDur Han Kwon

Publisher 

Korean Society of Applied Biological Chemistry

Issue Date 

2008

Citation 

Journal of Applied Biological Chemistry, vol. 51, no. 3, pp. 123-127

Keywords 

antiviral activitycytopathic effectsenterovirus 71origanum vulgarerosmarinus officinalis (Anna Rosemary)human enterovirus 71

Abstract 

Anti-enterovirus 71 (EV 71) activities of fifteen herb plant species extracts were examined by SRB assay, among which Origanum vulgare and Rosmarinus officinalis (Anna Rosemary) extracts exhibited the activities with IC50 of 8.28 and 8.17 μg/mL, respectively. Their 50% cytotoxicity concentrations (CC50) were 691.89 and 1104.19 μg/mL, and the therapeutic indices were 83.56 and 135.15, respectively. Amantadine (positive control) showed anti-EV 71 activity with 50% inhibitory concentration and CC50 of 4.46 and 145.22 μg/mL, respectively. Addition of the methanol extracts of O. vulgare and R. officinalis (Anna Rosemary) in EV 71-infected Vero cells strongly inhibited the formation of visible cytopathic effects without changing the normal morphology of the cells. These results indicate that methanol extracts of O. vulgare and R. officinalis (Anna Rosemary) may contain antiviral compound inhibiting the EV 71 replication.

ISSN 

1229-2737

Link 

http://dx.doi.org/10.3839/jabc.2008.023

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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