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Title 

Cyathuscavins A, B, and C, new free radical scavengers with DNA protection activity from the Basidiomycete Cyathus stercoreus

Authors 

H S KangK R KimE M JunS H ParkT S LeeJ W SuhJong Pyung Kim

Publisher 

Elsevier

Issue Date 

2008

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 14, pp. 4047-4050

Keywords 

cyathus stercoreusDNA protectionfree radical scavengerpolyketideplasmid DNAbasidiomycetesantioxidant activitycarbon nuclear magnetic resonanceDNA strand breakagedrug screening

Abstract 

Three new polyketides, cyathuscavins A (1), B (2), and C (3) were isolated from the mycelium culture of Cyathus stercoreus. The structures of the compounds were elucidated on the basis of NMR and mass spectroscopic data. Antioxidant activities of the compounds were evaluated by the scavenging ability against ABTS+, DPPH, and superoxide anion radicals. Cyathuscavins A-C showed significant antioxidant activity comparable to those of reference antioxidants, BHA and Trolox. Cyathuscavins A-C protected supercoiled plasmid DNA from Fe2+/H2O2-induced breakage.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2008.05.110

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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