상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of VCAM-1 expression

Authors 

D I SunI T NizamutdinovaY M KimX F CaiJung Joon LeeS S KangY S KimK M KangG Y ChaiK C ChangH J Kim

Publisher 

Elsevier

Issue Date 

2008

Citation 

International Immunopharmacology, vol. 8, no. 9, pp. 1272-1281

Keywords 

bisacuroneinflammatory diseasemetastasisNF-kappa Breactive oxygen speciesvascular cell adhesion molecule-1cancer cellcell nucleus membranedown regulationmonocyte

Abstract 

Bisacurone, one of the active compounds of the traditionally used indigenous herb Curcuma longa Linne (Zingiberaceae), has anti-oxidant, anti-inflammatory, and anti-metastatic activities. We studied how the level of vascular cell adhesion molecule-1 (VCAM-1), one of the key molecules in the development of atherosclerosis as well as carcinogenesis and metastasis, might be affected by bisacurone in tumor necrosis factor-alpha (TNF-α)-activated human umbilical vein endothelial cells (HUVECs). Bisacurone dose-dependently inhibited TNF-α-mediated expression of VCAM-1. It showed significant suppressive effect on ROS generation in response to TNF-α stimulation and it blocked nuclear factor-kappa B (NF-κB) p65 translocation into the nucleus and phosphorylation of inhibitory factor κBα (IκBα). It also inhibited phosphorylation of Akt and PKC, which are upstream in the regulation of VCAM-1 by TNF-α. Furthermore, bisacurone decreased U937 monocyte and human oral cancer cell (Hep-2, QLL-I, SCC-15) adhesion to HUVECs stimulated by TNF-α, suggesting that it may inhibit the binding of these cells by regulating the expression of critical adhesion molecules by TNF-α. Thus, bisacurone may be beneficial in the treatment of inflammatory diseases, such as atherosclerosis, where inflammatory monocytes are involved in their pathology, and, moreover, in the development of tumors.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2008.05.006

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)