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Title 

Antiinflammatory activity of methanol extract isolated from stem bark of Magnolia kobus

Authors 

Jong Soon KangKi Hoon LeeM H HanHyunju LeeJ M AhnS B HanG HanKiho LeeSong Kyu ParkHwan Mook Kim

Publisher 

Wiley-Blackwell

Issue Date 

2008

Citation 

Phytotherapy Research, vol. 22, no. 7, pp. 883-888

Keywords 

AP-1interleukin-1βmagnolia kobusnitric oxidetumor necrosis factor-αmethanolantiinflammatory activity

Abstract 

The present study reports the antiinflammatory activity of a methanol extract isolated from the stem bark of Magnolia kobus (MK). MK potently inhibited lipopolysaccharide (LPS)-induced production of nitric oxide and interleukin-1β (IL-1β) in RAW 264.7 cells, a murine macrophage-like cell line. The secretion of tumor necrosis factor-α (TNF-α) was also suppressed in LPS-stimulated RAW 264.7 cells although the magnitude of inhibition was weaker than that of nitric oxide and IL-1β. The mRNA expressions of inducible nitric oxide synthase (iNOS), IL-1β and TNF-α were also suppressed by MK in LPS-stimulated RAW 264.7 cells. Further study demonstrated that LPS-induced DNA binding of AP-1 and phosphorylation of c-jun TV-terminal kinase (JNK) were inhibited by MK treatment in RAW 264.7 cells, whereas phosphorylation of p38 mitogen-activated protein kinase was unaffected. Moreover, topical application of MK suppressed ear swelling in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation model. Collectively, these results suggest that MK exerts antiinflammatory effects in vitro and in vivo and this might be mediated, at least in part, by blocking AP-1 and JNK activation.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.2386

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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