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Title 

Inhibition of atopic dermatitis by topical application of silymarin in NC/Nga mice

Authors 

Jong Soon KangWoon Kee YoonM H HanH LeeChang Woo LeeKi Hoon LeeS B HanKiho LeeK H YangSong Kyu ParkHwan Mook Kim

Publisher 

Elsevier

Issue Date 

2008

Citation 

International Immunopharmacology, vol. 8, no. 10, pp. 1475-1480

Keywords 

atopic dermatitisIL-4NC/NgasilymarinTNF-αdrug inhibitionmousemouse strain

Abstract 

Silymarin has been known to inhibit chemical-induced irritant contact dermatitis. In the present study, we report that topical application of silymarin suppresses dust mite extract (DPE)-induced atopic dermatitis (AD) in NC/Nga mice. Repeated topical application of ears with DPE caused AD-like skin lesions in NC/Nga mice. However, silymarin reduced AD-like skin lesions in these mice, resulting in decreased ear swelling and leukocyte infiltration into the ear. Moreover, our results showed that mast cell infiltration into the ear was suppressed by silymarin treatment in DPE-treated NC/Nga mice. Silymarin also reduced plasma level of IL-4 and IgE in these mice. Further study demonstrated that the mRNA expression of IL-4 was increased and that of IFN-γ was decreased by DPE treatment in the ears of NC/Nga mice. However, DPE-induced changes in IL-4 and IFN-γ mRNA expression were reversed by silymarin. DPE-induced increase in TNF-α mRNA expression was also suppressed by silymarin treatment. The results presented in this report suggest that silymarin might be beneficial for the treatment of AD.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2008.06.004

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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