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Title 

Polychlorinated compounds with PPAR-γ agonistic effect from the medicinal fungus Phellinus ribis

Authors 

In Kyoung LeeJ H LeeBong Sik Yun

Publisher 

Elsevier

Issue Date 

2008

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 16, pp. 4566-4568

Keywords 

chlorophellinsphellinus ribispolychlorinated compoundsPPAR-γdrug effectfungiPPAR gamma

Abstract 

During the search for natural substances with PPAR-γ agonistic effect, unique polychlorinated compounds named chlorophellins A-C have been isolated together with the known compound, drosophilin A, from the methanolic extract of the fruiting body of the fungus Phellinus ribis. Their structures were assigned on the basis of NMR and mass spectrometric analyses. Chlorophellin C of compounds tested exhibited the most potent PPAR-γ agonistic effect and was comparable to rosiglitazone, a well-known PPAR-γ agonist that has been used for the therapy of type 2 diabetes.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2008.07.034

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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