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Title 

A cytotoxic and apoptosis-inducing sesquiterpenoid isolated from the aerial parts of Artemisia princeps PAMPANINI (Sajabalssuk)

Authors 

M H BangM W HanM C SongJ G ChoH G ChungTae Sook JeongK T LeeM S ChoiS Y KimN I Baek

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2008

Citation 

Chemical & Pharmaceutical Bulletin, vol. 56, no. 8, pp. 1168-1172

Keywords 

3-((S)-2-methylbutyryloxy)- costu-1(10),4(5)-dien-12,6α-olideapoptosisartemisia princepscarlaolide Acarlaolide Bcytotoxicitysesquiterpenoidcancer cell culturecolumn chromatographydrug cytotoxicity

Abstract 

Repeated silica gel and octadecyl silica gel (ODS) column chromatography of the aerial parts of Artemisia princeps PAMPANINI (Sajabalssuk) led to the isolation of a new sesquiterpenoid, 3-((S)-2-methylbutyryloxy)-costu-1(10),4(5)- dien-12,6α-olide (2), along with two previously reported sesquiterpenoids: 8α-angeloyloxy-3β,4β-epoxy-6βH,7αH,8βH-guaia- 1(10),11(13)-dien-12,6α-olide (1, carlaolide B) and 3β,4β-epoxy- 8α-isobutyryloxy-6βH,7αH,8βH-guaia-1(10),11(13)-dien-12, 6α-olide (3, carlaolide A). The structure of compound 2 was elucidated by spectroscopic data analysis, including one dimensional (1D) and two dimensional (2D) nuclear magnetic resonance (NMR) experiments. of the isolates, compound 2 exhibited potent cytotoxicity against human cervix adenocarcinoma cells and induced apoptosis.

ISSN 

0009-2363

Link 

http://dx.doi.org/10.1248/cpb.56.1168

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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