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Title 

Minisatellite polymorphisms of the SLC6A19: Susceptibility in hypertension

 

유전자 SLC6A19의 Minisatellite 다형성 : Susceptibility in hypertension

Authors 

S Y SeolSang-Yeop LeeY D KimE J DoJ A KwonS I KimIn-Sun ChuS H Leem

Publisher 

Elsevier

Issue Date 

2008

Citation 

Biochemical and Biophysical Research Communications, vol. 374, no. 4, pp. 714-719

Keywords 

essential hypertensionminisatellite polymorphismsneurotransmitter transporterSLC6A19VNTRDNA minisatelliteDNA polymorphismgenetic susceptibilityhypertension

Abstract 

The SLC6A19 is a human homolog of B0AT1 that encodes a neutral amino acid transporter. We examined the distribution of VNTR (variable number of tandem repeats; minisatellites) and conducted polymorphic analysis of SCL6A19 isolated from the genomic DNA of controls and multi-generational families. The SLC6A19 was found to contain seven blocks of minisatellites, 3 of which (SLC6A19-MS1, -MS4, and -MS7) showed polymorphism and were found to be transmitted through meiosis following Mendelian inheritance in seven families. These minisatellite polymorphisms may be useful markers for paternity mapping and DNA fingerprinting. Furthermore, we conducted a case-control study in which genomic DNA from 400 controls and 205 cases with essential hypertension was compared. A statistically significant association was identified between rare SLC6A19-MS7 alleles and the occurrence of hypertension (odds ratio, 7.87; 95% confidence interval, 0.88-70.66; and p = 0.028). These findings suggest that the rare SLC6A19-MS7 allele may be a risk factor for hypertension.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2008.07.094

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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