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Title 

Interactome analysis of yeast glutathione peroxidase 3

 

효모 GPx3의 사호작용단백질체학 분석

Authors 

Phil Young LeeKwang-Hee BaeChang Won KhoSunghyun KangD H LeeS ChoS KangSang Chul LeeByoung Chul ParkSung Goo Park

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2008

Citation 

Journal of Microbiology and Biotechnology, vol. 18, no. 8, pp. 1364-1367

Keywords 

glutathione peroxidase 3IP-2DEoxidative stressROSSSY protein 3yeastglutathione peroxidase

Abstract 

Oxidative stress damages all cellular constituents, and therefore, cell has to possess various defense mechanisms to cope. Saccharomyces cerevisiae, widely used as a model organism for studying cellular responses to oxidative stress, contains three glutathione peroxidase (Gpx) proteins. Among them, Gpx3 plays a major defense role against oxidative stress in S. cerevisiae. In this study, in order to identify the new interaction proteins of Gpx3, we carried out two-dimensional gel electrophoresis after immunoprecipitation (IP-2DE), and MALDI-TOF mass spectrometry. The results showed that several proteins including protein disulfide isomerase, glutaredoxin 2, and SSY protein 3 specifically interact with Gpx3. These findings led us to suggest the possibility that Gpx3, known as a redox sensor and ROS scavenger, has another functional role by interacting with several proteins with various cellular functions.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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