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Title 

Identification of proteins binding to decursinol by chemical proteomics

 

화학단백질체학을 이용한 디커시놀 결합 단백질의 발굴

Authors 

Hyo Jin KangTae-Sung YoonDae Gwin JeongYongmo KimJin Woong ChungJong Seong HaSung Sup ParkSeong Eon RyuS KimKwang-Hee BaeSang Jeon Chung

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2008

Citation 

Journal of Microbiology and Biotechnology, vol. 18, no. 8, pp. 1427-1430

Keywords 

anticancerchemical proteomicsdecursinolenolaseHsp90protein derivativebinding affinitydrug protein bindingproteomicsprotein binding

Abstract 

Decursinol, found in the roots of Angelica gigas Nakai, has been traditionally used to treat anemia and other various diseases. Recently, numerous biological activities such as cytotoxic effect on leukemia cells, and antitumor, neuroprotection, and antibacterial activities have been reported for this compound. Although a number of proteins including protein kinase C, androgen receptor, and acetylcholinesterase were proposed as molecular targets responsible for the activities of decursinol, they are not enough to explain such a diverse biological activity mentioned above. In this study, we employed a chemical proteomic approach, leading to identification of seven proteins as potential proteins interacting with decursinol. Most of the proteins contain a defined ATP or nucleic acid binding domain and have been implied to be involved in the pathogenesis and progression of various human diseases including cancer, autoimmune disorders, or neurodegenerative diseases. The present results may provide clues to understand the molecular mechanism of the biological activities shown by decursinol, an anticancer natural product.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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