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Title 

Killing rate curve and combination effects of surfactin C produced from Bacillus subtilis complex BC1212 against pathogenic Mycoplasma hyopneumoniae

Authors 

M H HwangMyung Hee KimE GebruB Y JungS P LeeS C Park

Publisher 

Springer Verlag (Germany)

Issue Date 

2008

Citation 

World Journal of Microbiology & Biotechnology, vol. 24, no. 10, pp. 2277-2282

Keywords 

FICkilling rate curveMICmycoplasma hyopneumoniaesurfactin Cchlorine compoundsbacillus subtilisminimal inhibitory concentrationsoxytetracycline (OTC)

Abstract 

This study evaluated the killing rate as well as the antimycoplasmal effect of surfactins isolated from Bacillus subtilis complex BC1212, either alone or in combination with various antibacterials against Mycoplasma hyopneumoniae. Prior to the killing rate and the combination effect studies of surfactins, the minimal inhibitory concentrations (MICs) of various antibacterials and surfactins (consisting of surfactins A, B, C, and D) against M. hyopneumoniae were investigated. The MIC of all surfactins was found to be 64 μg/ml. The MICs of colistin (COL), norfloxacin (NFX), oxytetracycline (OTC), streptomycin (SM) and tiamulin (TIA) were >256, 0.063, 0.025, 4, and 0.015 μg/ml, respectively. In the killing rate curve studies, surfactin C at 2× MIC and 4× MIC concentrations was found to reduce viability by >3 log 10 c.c.u./ml within 2-4 h of incubation. Combination of surfactin C with other antibacterials showed additive interaction from the viewpoint of fractional inhibitory concentration (FIC) index of >0.5 but ≤2 as a borderline. Taking all results into consideration, surfactin C may be useful as a preventive or therapeutic adjuvant in the pathogenesis of mycoplasmal infection.

ISSN 

0959-3993

Link 

http://dx.doi.org/10.1007/s11274-008-9752-0

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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