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Title 

Isolation of Sorangium cellulosum carrying epothilone gene clusters

Authors 

H HyunJ ChungJihoon KimJong Suk LeeByoung-Mog KwonKwang Hee SonK Cho

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2008

Citation 

Journal of Microbiology and Biotechnology, vol. 18, no. 8, pp. 1416-1422

Keywords 

epothilonemyxobacteriasorangium cellulosumgene clusterbacterial genebacterial geneticsbacterium isolationpolyangium cellulosumepothilone A

Abstract 

Epothilone and its analogs are a potent new class of anticancer compounds produced by myxobacteria. Thus, in an effort to identify new myxobacterial strains producing epothilone and its analogs, cellulose-degrading myxobacteria were isolated from Korean soils, and 13 strains carrying epothilone biosynthetic gene homologs were screened using a polymerase chain reaction. A migration assay revealed that Sorangium cellulosum KYC3013, 3016, 3017, and 3018 all produced microtubule-stabilizing compounds, and an LCMS/MS analysis showed that S. cellulosum KYC3013 synthesized epothilone A.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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