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Title 

Microarray study of genes differentially modulated in response to nitric oxide in macrophages

Authors 

X NanO MaengH ShinH J AnYoung Il YeomH LeeS G Paik

Publisher 

Zoological Society of Korea

Issue Date 

2008

Citation 

Animal Cells and Systems, vol. 12, no. 1, pp. 15-21

Keywords 

nitric oxidemicroarraymouse macrophage RAW264.7 cellsapoptosis

Abstract 

Nitric oxide (NO) has been known to play important roles in numerous physiologic processes including neurotransmission, vasorelaxation, and cellular apoptosis. Using a mouse cDNA gene chip, we examined expression patterns and time course of NO-dependent genes in mouse macrophage RAW264.7 cells. Genes shown to be upregulated more than two fold or at least at two serial time points were further selected and validated by RT-PCR. Finally, 81 selected genes were classified by function as signaling, apoptosis, inflammation, transcription, translation, ionic homeostasis and metabolism. Among those, genes related with signaling, apoptosis and inflammation, such as guanylate cyclase 1, soluble, alpha3 (Gucy1a3); protein kinase C, alpha (Pkcα); lymphocyte protein tyrosine kinase (Lck); BCL2/adenovirus E1B 19 kDa-interacting protein (Bnip3); apoptotic protease activating factor 1 (Apaf1); Xlinked inhibitor of apoptosis (Xiap); cyclin G1 (Ccng1); chemokine (C-C motif) ligand 4 (Ccl4); B cell translocation gene 2, anti-proliferative (Btg2); lysozyme 2 (Lyz2); secreted phosphoprotein 1 (Spp1); heme oxygenase (decycling) 1 (Hmox1); CD14 antigen (Cd14); and granulin (Grn) may play important roles in NO-dependent responses in murine macrophages.

ISSN 

1976-8354

Link 

http://dx.doi.org/10.1080/19768354.2008.9647149

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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