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Title 

Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis

 

오보바톨의 항암효과

Authors 

Su Kyung LeeHye Nan KimYeong-Rim KangChang Woo LeeHwan Mook KimDong Cho HanJ ShinK BaeByoung-Mog Kwon

Publisher 

Elsevier

Issue Date 

2008

Citation 

Bioorganic & Medicinal Chemistry, vol. 16, no. 17, pp. 8397-8402

Keywords 

antitumorapoptosishonokiolmagnolia obovata Thunbobovatolcancer growthcancer inhibitioncell proliferationcolorectal cancer

Abstract 

Neolignans such as obovatol, honokiol, and magnolol have been previously reported to show various biological activities including anti-inflammation and antitumor effects. This is the first demonstration on the in vivo antitumor effect of obovatol on human colorectal carcinoma SW620 cells. Nude mice were implanted with SW620 cells and fed with vehicle or 5 mg/kg/d dose of obovatol for 20 days. Obovatol inhibited tumor growth that accounted for 50% decrease in tumor volume and 44.6% decrease in tumor weight at the end of the experiment without any adverse health effect. In nude mice bearing SW620-incubated tumor, obovatol exhibited more potent antitumor activity than honolkiol. In addition, DNA flow cytometric analysis shows that obovatol progresses to apoptosis as detected by flow cytometry after double staining with annexin V and propidium iodide. Thus, we suggest that obovatol is a potent inducer of cell apoptosis in SW620 cells, and a potent antitumor agent.

ISSN 

0968-0896

Link 

http://dx.doi.org/10.1016/j.bmc.2008.08.033

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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