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Title 

Synthesis and cytotoxic activities of 2-alkyl-2,3-dihydro-1H-2,6,9-tri-azacyclopenta[b]anthracene-5,10-dions

Authors 

J H KwakK NamgoongJ K JungJungsook ChoHwan Mook KimSong Kyu ParkYoung Ah YooJoo Hee KwonH Lee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2008

Citation 

Archives of Pharmacal Research, vol. 31, no. 8, pp. 995-998

Keywords 

cytotoxic activitytriazacyclopenta[b]anthracene-5,10-dionesstructure activity relationsynthesisstructure-activity relationship

Abstract 

A series of 2-alkyl-2,3-dihydro-1H-2,6,9-triazacyclopenta[b]anthracene-5, 10-diones (4a-f) were synthesized and their in vitro cytotoxic activities were evaluated against six human cancer cell lines (HCT15, SK-OV-3, A549, SNB19, MCF7 and MCF7/ADR). A number of compounds including 4c and 4d showed 2-180 times more potent cytotoxic activity than doxorubicin against all human cancer cell lines tested. Furthermore, these compounds retained considerable cytotoxic activity against the doxorubicin-resistant cell line MCF7/ADR, implying their therapeutic potential to treat doxorubicin-resistant tumors.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-001-1258-6

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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