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Title 

An anti-viral peptide derived from the preS1 surface protein of hepatitis B virus

Authors 

D H KimY NiSi Hyung LeeS UrbanKyou Hoon Han

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2008

Citation 

BMB Reports, vol. 41, no. 9, pp. 640-644

Keywords 

hepatitis B virus (HBV)intrinsically unstructured protein (IUP)lipo-peptideslocal pre-structured motifnuclear magnetic resonance (Nmr)preSlantivirus agenthepatitis B vaccinepeptideprotein precursor

Abstract 

The preS1 surface protein of the hepatitis B virus (HBV) is a key factor involved in initial viral entry into hepatocytes. It has been long postulated that an anti-HBV effect should be achievable using peptide fragments of the preSl. Recent reports demonstrated that several preSl -derived lipo-peptides in genotype D HBV exhibit nano to picomolar inhibitory activity against HBV infection. In this study, an acylated analog of a preS1 fragment, a 21-residue lipo-peptide (named 7524 BVS7) with a sequence of palmitoyl- GMGTNLSVPNPLGFFPDHQLDC-NH2, from genotype C HBV was produced base upon a previous structural study and was shown potently inhibits HBV infection with an IC50 of ? 20 nM.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2008.41.9.640

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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