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Title 

Epigallocatechin gallate stimulates glucose uptake through the phosphatidylinositol 3-kinase-mediated pathway in L6 rat skeletal muscle cells

 

Epigallocatechin gallate는 L6마우스 골근세포 phosphatidylinositol 3-kinase-mediated pathway통해 포도당흡수 촉진

Authors 

K H JungH S ChoiD H KimM Y HanU J ChangS V YimB C SongChul Ho KimS A Kang

Publisher 

Mary Ann Liebert

Issue Date 

2008

Citation 

Journal of Medicinal Food, vol. 11, no. 3, pp. 429-434

Keywords 

AMP-activated protein kinaseepigallocatechin gallateglucose uptakephosphatidylinositol 3-kinaseskeletal muscleglucoseprotein kinase Bsb 203585glucose homeostasisrat

Abstract 

The effect of epigallocatechin gallate (EGCG) on glucose uptake was studied in L6 rat skeletal muscle cells. Glucose uptake assay revealed that EGCG increased glucose uptake >70% compared to control. EGCG-stimulated glucose uptake was blocked by LY294002, an inhibitor of phosphatidylinositol (PI) 3-kinase, which is a major regulatory molecule in glucose uptake pathways. However, AMP-activated protein kinase (AMPK), which is another crucial mediator in independent glucose uptake pathways, did not inhibit EGCG-stimulated glucose uptake by SB203585, a specific inhibitor of the AMPK downstream mediator, p38 mitogen-activated protein kinase (MAPK). We also found that EGCG increased the phosphorylation level of protein kinase B and PI 3-kinase activity, when assessed by PI 3-kinase assay, whereas no increase in the phosphorylation level of AMPK and p38 MAPK was observed. Taken together, these results suggest that EGCG might stimulate glucose uptake, not AMPK-mediated but PI 3-kinase-mediated, in skeletal muscle cells, thereby contributing to glucose homeostasis.

ISSN 

1096-620X

Link 

http://dx.doi.org/10.1089/jmf.2007.0107

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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