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Title 

Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT

Authors 

D O MoonM O KimY H ChoiHee Gu LeeN D KimG Y Kim

Publisher 

Elsevier

Issue Date 

2008

Citation 

FEBS Letters, vol. 582, no. 23, pp. 3367-3373

Keywords 

Aktc-MycgossypolhTERTtelomerasetelomerase reverse transcriptasehumansleukemia

Abstract 

Gossypol is a polyphenolic compound originally isolated from cottonseed that has long been used successfully as a contraceptive drug for males. However, the molecular mechanism of anti-telomerase effects of gossypol is not entirely understood. In this study, we observed direct cytotoxicity and inhibition of telomerase activity with downregulation of telomerase reverse transcriptase (hTERT) expression. Gossypol treatment resulted in a decrease of c-Myc expression and binding activity. Gossypol treatment also suppressed the activation of Akt, thereby inhibiting hTERT phosphorylation and translocation into the nucleus. We conclude that gossypol regulates the loss of telomerase activity through transcriptional and posttranslational modifications of hTERT.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/j.febslet.2008.08.029

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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