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Title 

A new antioxidant, clitocybin A, from the culture broth of Clitocybe aurantiaca

Authors 

Young Hee KimS M ChoJ W HyunIn Ja RyooSoo-Jin ChooSangku LeeS J SeokJ S HwangE D SohnB S YunK H BaeIck Dong Yoo

Publisher 

Nature Publishing Group

Issue Date 

2008

Citation 

Journal of Antibiotics, vol. 61, no. 9, pp. 573-576

Keywords 

antioxidant activityclitocybe aurantiacaclitocybin Acomet assay

Abstract 

Clitocybin A (1), a new antioxidant, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography and preparative HPLC. Its structure was determined as 4,6-dihydroxy-2-ρ-hydroxyphenyl- isoindol-1-one on the basis of the UV, NMR, and MS spectroscopic analysis. The compound 1 showed potent free radical scavenging activity against superoxide, ABTS, and DPPH radicals, and protective effect against cellular DNA damage induced by oxidative stress.

ISSN 

0021-8820

Link 

http://dx.doi.org/10.1038/ja.2008.77

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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