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Title 

Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast

Authors 

A RoguevS BandyopadhyayM ZofallK ZhangT FischerS R CollinsH QuM ShalesH O ParkJ HaylesKwang Lae HoeDong Uk KimT IdekerS I GrewalJ S WeissmanN J Krogan

Publisher 

American Association for the Advancement of Science

Issue Date 

2008

Citation 

Science, vol. 322, no. 5900, pp. 405-410

Keywords 

conservationgenetic conservation

Abstract 

An epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces pombe, by systematically measuring the phenotypes associated with pairs of mutations. This high-density, quantitative genetic interaction map focused on various aspects of chromosome function, including transcription regulation and DNA repair/replication. The E-MAP uncovered a previously unidentified component of the RNA interference (RNAi) machinery (rsh1) and linked the RNAi pathway to several other biological processes. Comparison of the S. pombe E-MAP to an analogous genetic map from the budding yeast revealed that, whereas negative interactions were conserved between genes involved in similar biological processes, positive interactions and overall genetic profiles between pairs of genes coding for physically associated proteins were even more conserved. Hence, conservation occurs at the level of the functional module (protein complex), but the genetic cross talk between modules can differ substantially.

ISSN 

0036-8075

Link 

http://dx.doi.org/10.1126/science.1162609

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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