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Title 

Penicillium griseofulvum F1959, high-production strain of pyripyropene A, specific inhibitor of Acyl-CoA: cholesterol acyltransferase 2

Authors 

Jung Ho ChoiMun Chual RhoSeung Woong LeeJi Na ChoiHee Jeong LeeKyung Sook BaeK KimYoung Kook Kim

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2008

Citation 

Journal of Microbiology and Biotechnology, vol. 18, no. 10, pp. 1663-1665

Keywords 

acyl-coenzyme Aatherosclerosischolesterol acyltransferase (ACAT)penicillium griseofulvum F1959pyripyropene A

Abstract 

Acyl-coenzyme A: cholesterol acyltransferase (ACAT) catalyzes cholesterol esterification and plays an important role in the intestinal absorption of cholesterol, hepatic production of lipoproteins, and accumulation of cholesteryl ester within cells. During the course of screening to find ACAT inhibitors from microbial sources, the present authors isolated pyripyropene A from Penicillium griseofulvum F1959. Pyripyropene A, an ACAT2-specific inhibitor, has already been produced from Aspergillus fumigatus. Yet, Aspergillus fumigatus is a pathogen and only produces a limited amount of pyripyropene A, making the isolation of pyripyropene A troublesome. In contrast, Penicillium griseofulvum F1959 was found to produce approximately 28 times more pyripyropene A than Aspergillus fumigatus, plus this report also describes the ideal conditions for the production of pyripyropene A by Penicillium griseofulvum F1959 and its subsequent purification.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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