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Title 

Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B

Authors 

P T ThuongChul Ho LeeT T DaoP H NguyenW G KimS J LeeW K Oh

Publisher 

American Chemical Society

Issue Date 

2008

Citation 

Journal of Natural Products, vol. 71, no. 10, pp. 1775-1778

Keywords 

diospyros kaki extractprotein tyrosine phosphatase 1Bdiospyros kakiplant leafdiospyrosplant leavesprotein tyrosine phosphatase, non-receptor type 1

Abstract 

Phytochemical study on a methanol-soluble extract of the leaves of persimmon (Diospyros kaki) resulted in the isolation of two new ursane-type triterpenoids, 3α,19α-dihydroxyurs-12,20(30)-dien-24,28-dioic acid (1) and 3α,19α-dihydroxyurs-12-en-24,28-dioic acid (2), together with 12 known ursane- and oleanane-type triterpenoids (3-14). Triterpenoids with a 3β-hydroxy group were found to inhibit protein tyrosine phosphatase 1B (PTP1B) activity, with IC50 values ranging from 3.1 ± 0.2 to 18.8 ± 1.3 μM, whereas those with a 3α-hydroxy moiety were not active.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np800298w

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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