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Title 

Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression

Authors 

N T DatJ H LeeKyeong LeeYoung-Soo HongY H KimJung Joon Lee

Publisher 

American Chemical Society

Issue Date 

2008

Citation 

Journal of Natural Products, vol. 71, no. 10, pp. 1696-1700

Keywords 

animalsDNA/drug effectsfabaceaehela cellshumansKoreamacrophagesmicemolecular structureNF-kappa B

Abstract 

NF-κB is known to play a crucial role in the regulation of genes controlling the immune system, apoptosis, tumor cell growth, and tissue differentiation. Bioassay-guided fractionation of the n-hexane-soluble fraction of a methanol extract of Amorpha fruticosa afforded four new compounds, 5, 7, 8, and 9, and eight known compounds. Their structures were elucidated by spectroscopic methods. All compounds inhibited NF-κB activity, and tephrosin (1), 11-hydroxytephrosin (2), and deguelin (3) were the most active, with IC50 values of 0.11, 0.19, and 0.22 μM, respectively, in TNF-α-stimulated HeLa cell-based reporter gene assays. Further investigations showed that compounds 1, 5, and 6 blocked NF-κB/DNA binding activity and suppressed the expression of NF-κB target genes.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np800383q

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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