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Title 

Viridicatumtoxin B, a new anti-MRSA agent from Penicillium so. FR11

Authors 

C J ZhengHyung Eun YuE H KimWon Gon Kim

Publisher 

Nature Publishing Group

Issue Date 

2008

Citation 

Journal of Antibiotics, vol. 61, no. 10, pp. 633-637

Keywords 

antibacterialMRSApenicilliumtetracyclineviridicatumtoxin Bantiinfective agentquinoline derived antiinfective agenttetracycline derivativeunclassified drugvancomycin

Abstract 

A new tetracycline-type antibiotic named viridicatumtoxin B along with the known compound viridicatumtoxin has been isolated from the mycelium of liquid fermentation cultures of Penicillium sp. FR11. The structure of viridicatumtoxin B was determined on the basis of MS and NMR data. Viridicatumtoxin B inhibited the growth of Staphylococcus aureus including methicillin-resistant S. aureus and quinolone-resistant S. aureus with MIC (μg/ml) of 0.5, which is similar with that of vancomycin, but 8-64 times higher activity than that of tetracycline.

ISSN 

0021-8820

Link 

http://dx.doi.org/10.1038/ja.2008.84

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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