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Title 

Lignans from the fruits of Forsythia suspensa (Thunb.) vahl protect high-density lipoprotein during oxidative stress

Authors 

M J ChangT M HungB S MinJ C KimM H WooJ S ChoiHyeong Kyu LeeK Bae

Publisher 

Japan Society for Bioscience, Biotechnology and Agrochemistry

Issue Date 

2008

Citation 

Bioscience Biotechnology and Biochemistry, vol. 72, no. 10, pp. 2750-2755

Keywords 

forsythia suspensehuman high-density lipoproteinlignanlipid peroxidationoleaceaefruitsforsythialignansforsythia suspensa

Abstract 

The objective of the present study was to investigate the beneficial properties lignan compounds obtained from the fruits of Forsythia suspensa (Thunb.) Vahl (Oleaceae) for protecting human high-density lipoprotein (HDL) against lipid peroxidation. The isolated compounds (1-8) inhibited the generation of thiobarbituric acid-reactive substances (TBARS) in a dose-dependent manner with IC50 values from 8.5 to 18.7 μM, since HDL oxidation mediated by catalytic Cu2+. They also exerted an inhibitory effect against thermo-labile radical initiator (AAPH)-induced lipid peroxidation of HDL with IC50 values from 12.1 to 51.1 μM. Compounds 1 and 5 exerted inhibitory effects against the Cu2+-induced lipid peroxidation of HDL, as shown by an extended lag time prolongation at the concentration of 3.0 μM. These results suggest that the antioxidative effects of F. suspensa are due to its lignans and that these constituents may be useful for preventing the oxidation of HDL.

ISSN 

0916-8451

Link 

http://dx.doi.org/10.1271/bbb.80392

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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