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Title 

Upregulation of NF-κB upon differentiation of mouse embryonic stem cells

Authors 

Y E KimH B KangJ A ParkKi Hoan NamH J KwonY Lee

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2008

Citation 

BMB Reports, vol. 41, no. 10, pp. 705-709

Keywords 

differentiationembryonic stem cellsexpressionNF-κBupregulationimmunoglobulin enhancer binding proteincell differentiationcell lineembryonic stem cellmetabolism

Abstract 

NF-κB is a transcriptional regulator involved in many biological processes including proliferation, survival, and differentiation. Recently, we reported that expression and activity of NF-κB is comparatively low in undifferentiated human embryonic stem (ES) cells, but increases during differentiation. Here, we found a lower expression of NF-κB p65 protein in mouse ES cells when compared with mouse embryonic fibroblast cells. Protein levels of NF-κB p65 and relB were clearly enhanced during retinoic acid-induced differentiation. Furthermore, increased DNA binding activity of NF-κB in response to TNF-α, an agonist of NF-κB signaling, was seen in differentiated but not undifferentiated mouse ES cells. Taken together with our previous data in human ES cells, it is likely that NF-κB expression and activity of the NF-κB signaling pathway is comparatively low in undifferentiated ES cells, but increases during differentiation of ES cells in general.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2008.41.10.705

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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