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Title 

Bavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia

 

파고지로부터 분리한 ACAT저해물질 bavachin과 isobavachalcone

Authors 

Jung Ho ChoiMun Chual RhoSeung Woong LeeJi Na ChoiK KimG Y SongYoung Kook Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2008

Citation 

Archives of Pharmacal Research, vol. 31, no. 11, pp. 1419-1423

Keywords 

acyl-coenzyme Acholesterol acyltransferase (ACAT)atherosclerosisenzyme assayhypolipidemiaprenylated flavonoidsPsoralea corylifoliabavachinenzyme inhibitorisobavachalconesterol o-acyltransferase

Abstract 

Acyl-coenzyme A: cholesterol acyltransferase (ACAT) catalyzes cholesterol esterification and plays important roles in intestinal absorption of cholesterol, hepatic production of lipoproteins and accumulation of cholesteryl ester within macrophages and smooth muscle cells. Ethanol extract of Psoralea corylifolia showed a significant inhibition of ACAT enzyme. Via bioactivity-guided fractionation of the ethanol extract of Psoralea corylifolia, two prenylated flavonoids were isolated. Their structures were determined as bavachin (1) and isobavachalcone (2) by spectroscopic analysis (1H-, 13C-NMR, 2DNMR, and ESI-MS). The IC50 values were 86.0 (1) and 48.0 (2) μM in the ACAT assay system using rat liver microsome. Compound 2 also decreased cholesteryl ester formations in HepG2 cells. In addition, this compound showed a noncompetitive type of inhibition of ACAT.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-001-2126-x

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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