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Title 

Phytochemical investigation of Tiarella polyphylla

Authors 

G ShenSei Ryang OhB S MinJoongku LeeKyung Seop AhnY H KimHyeong Kyu Lee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2008

Citation 

Archives of Pharmacal Research, vol. 31, no. 1, pp. 10-16

Keywords 

anti-complementary activityflavonoidssaxifragaceaesteroidstiarella polyphyllatriterpenoids

Abstract 

Seven flavonoids (1-7), two triterpenoids (8 and 9) and four steroids (10, 11, 12 and 13) were isolated from the whole plant of Tiarella polyphylla. Based on the physicochemical and spectroscopic analyses, their structures were identified as myricetin (1), astragalin (2), afzelin (3), quercitrin (4), myricitin (5), nicotiflorin (6), isoquercitrin (7), tiarellic acid (8), 3β-hydroxy-20(29)lupen-27-oic acid (9), β-sitosterol-3-O-β-D- glucoside (10), stigmasterol-3-O-β-D-glucoside (11), β-sitosterol (12) and ergosterol endoperoxide (13). All 13 compounds, with the exception of tiarellic acid were isolated for the first time from T. polyphylla. In the anti-complementary assay, the steroids (12 and 13) exhibited potent activities; whereas, the flavonoids (1 to 7) showed weak or no activities, but even the triterpenoids (8 and 9) and steroidal saponins (10 and 11) evoked hemolysis. ⓒ 2008 The Pharmaceutical Society of Korea.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-008-1113-x

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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