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Title 

Flavanones from the stem bark of Erythrina abyssinica

Authors 

L CuiP T ThuongHyun Sun LeeD T NdintehJ T MbaforZ T FomumW K Oh

Publisher 

Elsevier

Issue Date 

2008

Citation 

Bioorganic & Medicinal Chemistry, vol. 16, no. 24, pp. 10356-10362

Keywords 

2,2-dimethylpyrano ringerythrina abyssinicaflavanoneflavanonesPTP1B inhibitorerythrina extractplant barkplant stems

Abstract 

Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of PTP1B in an in vitro assay with IC50 values ranging from 13.9 ± 2.1 to 19.0 ± 1.8 μM. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B.

ISSN 

0968-0896

Link 

http://dx.doi.org/10.1016/j.bmc.2008.10.012

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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