상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Alcohol enhances Abeta42-induced neuronal cell death through mitochondrial dysfunction

Authors 

D Y LeeKyu-Sun LeeH J LeeH Y JungJ Y LeeS H LeeY C YounK M SeoJ H LeeW B LeeS S Kim

Publisher 

Elsevier

Issue Date 

2008

Citation 

FEBS Letters, vol. 582, no. 30, pp. 4185-4190

Keywords 

alzheimer diseaseamyloid beta-proteinapoptosiscell line, tumorethanolhumansmembrane potential, tochondrialmitochondrianeuronsoligonucleotides, antisense

Abstract 

Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Epidemiological studies have indicated that alcohol consumption plays a role in the development of AD. Here we show that alcohol exposure has a synergistic effect on Abeta-induced neuronal cell death. Abeta-treated cultured neurons displayed spontaneous generation of reactive oxygen species (ROS), disruption of their mitochondrial membrane potential, induction of caspase-3 and p53 activities, and loss of cell viability. Alcohol exposure facilitated Abeta-induced neuronal cell death. Our study shows that alcohol consumption enhances Abeta-induced neuronal cell death by increasing ROS and mitochondrial dysfunction.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/j.febslet.2008.11.007

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)