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Title 

Transcriptome analysis and identification of regulators for long-term plasticity in Aplysia kurodai

Authors 

Y S LeeS L ChoiTae Hyung KimJ A LeeH K KimH KimD J JangJ J LeeSung Hoon LeeGwang Sik ShinC B KimY SuzukiS SuganoT KuboL L MorozE R KandelJong Hwa ParkB K Kaang

Publisher 

National Academy of Sciences

Issue Date 

2008

Citation 

Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 47, pp. 18602-18607

Keywords 

AplysiaAplysia kurodaimicroarray analysisplasticityLong-Term PotentiationNeuronal PlasticityAplysia californica

Abstract 

The marine mollusk Aplysia is a useful model organism for studying the cellular bases of behavior and plasticity. However, molecular studies of Aplysia have been limited by the lack of genomic information. Recently, a large scale characterization of neuronal transcripts was performed in A. californica. Here, we report the analysis of a parallel set of neuronal transcripts from a closely related species A. kurodai found in the northwestern Pacific. We collected 4,859 nonredundant sequences from the nervous system tissue of A. kurodai. By performing microarray and real-time PCR analyses, we found that ApC/EBP, matrilin, antistasin, and eIF3e clones were significantly up-regulated and a BAT1 homologous clone was significantly down-regulated by 5-HT treatment. Among these, we further demonstrated that the Ap-eIF3e plays a key role in 5-HT-induced long-term facilitation (LTF) as a positive regulator.

ISSN 

0027-8424

Link 

http://dx.doi.org/10.1073/pnas.0808893105

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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