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Title 

Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers

 

아토피 환자의 혈청 단백질체 분석

Authors 

Won Kon KimH R HwangDo-Hyoung KimPhil Young LeeY J InH Y RyuSung Goo ParkKwang-Hee BaeSang Chul Lee

Publisher 

Korean Society of Medical Biochemistry

Issue Date 

2008

Citation 

Experimental and Molecular Medicine, vol. 40, no. 6, pp. 677-685

Keywords 

apolipoproteins ECD5L protein, humandermatitis, atopicglycoproteinsplasmaproteomicscd5l proteinatopic dermatitisblood analysisprotein analysis

Abstract 

Atopic dermatitis (AD) is an inflammatory skin disorder that is both uncomfortable and distressing to patients, and its prevalence has been steadily increasing. It is obvious that the identification of efficient markers of AD in plasma would offer the possibility of effective diagnosis, prevention, and treatment strategies. In this study, a proteomic approach was used to analyze plasma glycoproteins from both children with AD and healthy child donors. Several protein spots showing significant quantitative changes in the AD patients were identified. Through sequential studies, it was confirmed that CD5L and ApoE were significantly up-regulated or down-regulated, respectively, in the plasma from AD patients compared with that from healthy donors. In addition, we suggest that the up-regulated CD5L in AD patients causes eosinophilia by inhibiting apoptosis or promoting the proliferation of eosinophils either in combination with or without IL-5. The glycoproteomic data in this study provides clues to understanding the mechanism of atopic alterations in plasma and suggests AD-related proteins can be used as candidate markers for AD.

ISSN 

1226-3613

Link 

http://dx.doi.org/10.3858/emm.2008.40.6.677

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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