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Title 

Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus

Authors 

Hwa-Jung ChoiJ H KimC H LeeY J AhnJ H SongS H BaekDur Han Kwon

Publisher 

Elsevier

Issue Date 

2009

Citation 

Antiviral Research, vol. 81, no. 1, pp. 77-81

Keywords 

antiviral activityhouttuynia cordatporcine epidemic diarrhea virusquercetin 7-rhamnosidediarrheaquercetinquercetin 7 rhamnosideporcine epidemic diarrhea virus infectionstructure activity relationvirus infection

Abstract 

Porcine epidemic diarrhea virus (PEDV) is the predominant cause of severe entero-pathogenic diarrhea in swine. The lack of effective therapeutical treatment underlines the importance of research for new antivirals. In this study, we identified Q7R, which actively inhibited PEDV replication with a 50% inhibitory concentration (IC50) of 0.014 μg/mL. The 50% cytotoxicity concentration (CC50) of Q7R was over 100 μg/mL and the derived therapeutic index was 7142. Several structural analogues of Q7R, quercetin, apigenin, luteolin and catechin, also showed moderate anti-PEDV activity. Antiviral drugs and natural compounds revealed ribavirin, interferon-α, coumarin and tannic acid have relative weaker efficacy compared to Q7R. Q7R did not directly interact with or inactivate PEDV particles and affect the initial stage of PEDV infection by interfering of PEDV replication. Also, the effectiveness of Q7R against the other two viruses (TGEV, PRCV) was lower compared to PEDV. Q7R could be considered as a lead compound for development of anti-PEDV drugs to may be used to during the early stage of PEDV replication and the structure-activity data of Q7R may usefully guideline to design other related antiviral agents.

ISSN 

0166-3542

Link 

http://dx.doi.org/10.1016/j.antiviral.2008.10.002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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