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Title 

Simultaneous intracellular delivery of targeting antibodies and functional nanoparticles with engineered protein G system

Authors 

Yong Taik LimMi Young JoJeong Min LeeSang Jeon ChungBong Hyun Chung

Publisher 

Elsevier

Issue Date 

2009

Citation 

Biomaterials, vol. 30, no. 6, pp. 1197-1204

Keywords 

cell imagingengineered proteingoldintracellular deliverynanoparticlesurface modificationfunctional nanoparticlesG systemsmulti-functional

Abstract 

Cellular internalization of functional nanoparticles that have optical and magnetic properties is very important in the cellular imaging and manipulation of specifically targeted biomolecules. In this study, a robust method to deliver functional nanoparticles and targeting antibodies into cells was suggested. The engineered protein G system, which contains an affinity tag and a cell penetration peptide in the N- and C-terminals, respectively, can capture surface-modified nanoparticles and antibodies without chemical reaction, and then non-invasively deliver them into the cells. Finally, gold-coated iron oxide nanoparticle/engineered protein G hybrid systems were successfully employed as multifunctional cargo systems for the targeting, imaging, and manipulation of mitochondria.

ISSN 

0142-9612

Link 

http://dx.doi.org/10.1016/j.biomaterials.2008.11.007

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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