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Title 

Hepatitis B virus-X protein recruits histone deacetylase 1 to repress insulin-like growth factor binding protein 3 transcription

Authors 

J K ShonBo Hwa ShonIn-Young ParkS U LeeL FaK Y ChangJ H SHinYoung Ik Lee

Publisher 

Elsevier

Issue Date 

2009

Citation 

Virus Research, vol. 139, no. 1, pp. 14-21

Keywords 

chromatin immunoprecipitationhistone deacetylase 1immunoprecipitationinsulin-like growth factor binding protein-3insulin-like growth factor type 1trichostatin Ahepatitis B virus X proteinsomatomedin binding protein 3transcription factor Sp1

Abstract 

Hepatitis B virus (HBV), a major causative agent of hepatocelluar carcinoma (HCC), encodes an oncogenic X-protein (HBx) which has been known as a transcriptional transactivator on multiple viral and celluar promoters. In the report, we verified that HBx transcriptionally repress insulin-like growth factor binding protein-3 (IGFBP-3) by promoting HBx/histone deacetylase 1 (HDAC1) complex formation. HBx recruited HDAC1 forms complex with Sp1 in a p53-independent manner) and deacetylates Sp1 which resulted in the diminished binding of Sp1 on targeted DNA during transcriptional repression. Deacetylation of Sp1 by HBx recruited HDAC1 likely to be a part of the mechanism that controls HBx induced IGFBP-3 repression and the modification of chromatin structure. ⓒ 2008 Elsevier B.V. All rights reserved.

ISSN 

0168-1702

Link 

http://dx.doi.org/10.1080/07391102.2008.10507254

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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