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Title 

Low dose estrogen supplementation reduces mortality of mice in estrogen-dependent human tumor xenograft model

Authors 

Jong Soon KangKang Moo rimS B HanWoon Kee YoonKimlee taek changKi Hoon LeeKiho LeeSong Kyu ParkHwan Mook Kim

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2009

Citation 

Biological & Pharmaceutical Bulletin, vol. 32, no. 1, pp. 150-152

Keywords 

breast cancerestrogenMCF-7tumor xenograft modelanimal modelestrogen therapylow drug dosemortalitymouse

Abstract 

Breast cancer is one of the most frequent female cancers in the Western world. Perturbation of estrogen levels by hormone replacement therapy or pregnancy is associated with a variety of diseases, including breast cancer. Estrogen supplementation is required to establish appropriate animal models for estrogen-related diseases. In this report, we demonstrated that supplementation with high doses of 17β-estradiol results in deaths in estrogen-dependent MCF-7 tumor xenograft model. Renal damage and bladder stone formation was implicated as a major cause of death. The mortality rate was significantly reduced when mice received a low dose of 17β-estradiol. We also confirmed that low dose of 17β-estradiol supplementation can support the growth of tumors in MCF-7 tumor xenograft model. These results suggest that low dose estrogen supplementation may be more appropriate in estrogen-dependent tumor xenograft models.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.32.150

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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