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Title 

Construction and performance test of a multiplexed multistage (MSn) time-of-flight mass spectrometer

Authors 

Y S ShinJeong Hee MoonM S Kim

Publisher 

American Chemical Society

Issue Date 

2008

Citation 

Analytical Chemistry, vol. 80, no. 24, pp. 9700-9704

Keywords 

amineshigh performance liquid chromatographymass spectrometersmass spectrometrynegative ionsphotoexcitationhigh voltagesion analysesion masseslaser desorption ionizations

Abstract 

A time-of-flight mass spectrometer equipped with two reflectrons was constructed for multiplexed photodissociation tandem mass spectrometry of peptide ions generated by matrix-assisted laser desorption ionization. A linear reflectron was used for high-resolution selection of a precursor ion while a quadratic reflectron was used for product ion analysis. With the photoexcitation of a precursor ion inside a cell floated at high voltage, information (MS 3) on intermediate ions generating a particular product ion was obtained. Fully multiplexed detection resulted in good MS3 signal levels. Use of the quadratic reflectron allowed intermediate ion mass determination within 4 Da. The possibility of further extending the technique and its analytical potential are discussed.

ISSN 

0003-2700

Link 

http://dx.doi.org/10.1021/ac801675r

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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