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Title 

Transcriptome analysis of the zebrafish mind bomb mutant

Authors 

J HwangH S KimJ W SeokJ D KimS KounS Y ParkJ LeeK S KimKyu Tae ChangZ Y RyooS M WangT L HuhS Lee

Publisher 

Springer Verlag (Germany)

Issue Date 

2009

Citation 

Molecular Genetics and Genomics, vol. 281, no. 1, pp. 77-85

Keywords 

genome-wide analysismind bombSAGEtranscriptome

Abstract 

Mind bomb (Mib) facilitates Notch signaling pathway by promoting the endocytosis of Notch ligand. The zebrafish mibta52b mutant has a defect in its ubiquitin ligase activity which is necessary to inhibit the neurogenesis, resulting in a neuronal hyperplasia. Several genes regulated in the mibta52b mutant have been well established, however, there were relatively few reports about the transcriptome profile. To identify the genes differentially expressed in the mibta52b mutant, genome-wide analysis was performed using serial analysis of gene expression. Three hundred and thirty-five transcripts were identified whose expressions were significantly altered in the mibta52b mutant as compared with the wild-type. Interestingly, it was suggested that the mibta52b mutation may affect not only neurogenesis but also mesoderm development. These results provide new insights into Notch signaling pathway.

ISSN 

0026-8925

Link 

http://dx.doi.org/10.1007/s00438-008-0395-5

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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