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Title 

Mouse period 2 mRNA circadian oscillation is modulated by PTP-mediated rhythmic mRNA degradation

Authors 

K C WooTae-Don KimK H LeeD Y KimW KimK Y LeeK T Kim

Publisher 

Oxford University Press

Issue Date 

2009

Citation 

Nucleic Acids Research, vol. 37, no. 1, pp. 26-37

Keywords 

3' untranslated regionsanimalsbinding sitescell cycle proteinscell linecircadian rhythmcricetinaedown-regulationhumansmice

Abstract 

Circadian mRNA oscillations are the main feature of core clock genes. Among them, period 2 is a key component in negative-feedback regulation, showing robust diurnal oscillations. Moreover, period 2 has been found to have a physiological role in the cell cycle or the tumor suppression. The present study reports that 3'-untranslated region (UTR)-dependent mRNA decay is involved in the regulation of circadian oscillation of period 2 mRNA. Within the mper2 3'UTR, both the CU-rich region and polypyrimidine tract-binding protein (PTB) are more responsible for mRNA stability and degradation kinetics than are other factors. Depletion of PTB with RNAi results in mper2 mRNA stabilization. During the circadian oscillations of mper2, cytoplasmic PTB showed a reciprocal expression profile compared with mper2 mRNA and its peak amplitude was increased when PTB was depleted. This report on the regulation of mper2 proposes that post-transcriptional mRNA decay mediated by PTB is a fine-tuned regulatory mechanism that includes dampening-down effects during circadian mRNA oscillations.

ISSN 

0305-1048

Link 

http://dx.doi.org/10.1093/nar/gkn893

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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