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Title 

EVOG: a database for evolutionary analysis of overlapping genes

Authors 

Dae Soo KimC Y ChoJae Won HuhH S KimH G Cho

Publisher 

Oxford University Press

Issue Date 

2009

Citation 

Nucleic Acids Research, vol. 37, no. DB, pp. D698-D702

Keywords 

chimpanzeecomputer interfacedrosophilaevolutionary visualizer for overlapping genes databasegene sequencegenetic analysisgenetic databasehumanhuman genomemarmoset

Abstract 

Overlapping genes are defined as a pair of genes whose transcripts are overlapped. Recently, many cases of overlapped genes have been investigated in various eukaryotic organisms; however, their origin and transcriptional control mechanism has not yet been clearly determined. In this study, we implemented evolutionary visualizer for overlapping genes (EVOG), a Web-based DB with a novel visualization interface, to investigate the evolutionary relationship between overlapping genes. Using this technique, we collected and analyzed all overlapping genes in human, chimpanzee, orangutan, marmoset, rhesus, cow, dog, mouse, rat, chicken, Xenopus, zebrafish and Drosophila. This integrated database provides a manually curated database that displays the evolutionary features of overlapping genes. The EVOG DB components included a number of overlapping genes (10074 in human, 10 009 in chimpanzee, 67 039 in orangutan, 51 001 in marmoset, 219 in rhesus, 3627 in cow, 209 in dog, 10 700 in mouse, 7987 in rat, 1439 in chicken, 597 in Xenopus, 2457 in zebrafish and 4115 in Drosophila). The EVOG database is very effective and easy to use for the analysis of the evolutionary process of overlapping genes when comparing different species. Therefore, EVOG could potentially be used as the main tool to investigate the evolution of the human genome in relation to disease by comparing the expression profiles of overlapping genes.

ISSN 

0305-1048

Link 

http://dx.doi.org/10.1093/nar/gkn813

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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