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Title 

돌단풍(Aceriphyllum rossii)에서 분리한 플라보노이드의 항암활성

 

Anti-cancer activity of flavonoids from Aceriphyllum rossii

Authors 

E M AhnJ T HanByoung-Mog KwonS H KimN I Baek

Publisher 

Korean Society for Applied Biological Chemisty

Issue Date 

2008

Citation 

Journal of Korean Society for Applied Biological Chemistry, vol. 51, no. 4, pp. 309-315

Keywords 

aceriphyllum rossiianti-cancercell migrationflavonol glycosideFPTaseH-ras

Abstract 

The methanol extract from the aerial parts of Aceriphyllum rossii was fractionated into ethyl acetate, n-BuOH and H2O layers through solvent fractionation. Repeated silica gel column chromatography of EtOAc and n-BuOH layers afforded five flavonol glycosides. They were identified as astragalin (1), kaempferol 3-O-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (2), rutin (3), kaempferol 3-O-α-L-rhamnopyranosyl (1→4)-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (4), and quercetin 3-O-α-L-rhamnopyranosyl (1→4)-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (5) on the basis of spectroscopic data. All of them showed an inhibition in farnesyl protein tranferase (FPTase) activity, and rutin (3) inhibited the growth of rat H-ras cell and the cell migration of human umbilical vein endothelial cells (HUVECs).

ISSN 

1738-2203

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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