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Title 

Antiviral activity of raoulic acid from Raoulia australis against Picornaviruses

Authors 

Hwa-Jung ChoiC H LimJ H SongS H BaekDur Han Kwon

Publisher 

Elsevier

Issue Date 

2009

Citation 

Phytomedicine, vol. 16, no. 1, pp. 35-39

Keywords 

antiviral activityraoulia australisraoulic acidantiviral agentsraoulia

Abstract 

RNA viruses are a major source of respiratory diseases worldwide. The lack of effective therapeutical treatment underlines the importance of research for new antiviral compounds. Raoulic acid is a principal ingredient of the plant Raoulia australis Hook. F. Antiviral assay using cytopathic effect (CPE) reduction method showed that raoulic acid possessed strong antiviral activity against human rhinovirus 2 (HRV2) with a 50% inhibition concentration (IC50) value of less than 0.1 μg/ml, human rhinovirus 3 (HRV3) with a IC50 value of 0.19 μg/ml, coxsackie B3 (CB3) virus with IC50 values of 0.33 μg/ml, coxsackie B4 (CB4) virus with IC50 values of 0.40 μg/ml, and enterovirus 71 (EV71) virus with IC50 values of less than 0.1 μg/ml. However, the compound did not possess antiviral activity against influenza A (Flu A/PR, Flu A/WS, H1N1) and B viruses at four concentrations ranging from 0.1 to 100 μg/ml.

ISSN 

0944-7113

Link 

http://dx.doi.org/10.1016/j.phymed.2008.10.012

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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