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Title 

Synthesis and biological evaluation of decursin, prantschimgin and their derivatives

Authors 

Y XiaK H MinKyeong Lee

Publisher 

The Korean Chemical Society

Issue Date 

2009

Citation 

Bulletin of the Korean Chemical Society, vol. 30, no. 1, pp. 43-48

Keywords 

coumarinsdecursinmultidrug resistanceP-glycoproteinprantschimginderivativessynthesis (chemical)

Abstract 

The synthesis of coumarin-based natural products and their derivatives is described. In vitro MDR reversal activities of the synthesized compounds were evaluated in P-glycoprotein over-expressing human sarcoma cell line MES-SA/DX5. Some of the coumarin derivatives were found to show potent MDR reversal activity. In particular, pyridyl derivative (15e) exhibited more potency than verapamil.

ISSN 

0253-2964

Link 

http://dx.doi.org/10.5012/bkcs.2009.30.1.043

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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