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Title 

Upregulation and secretion of macrophage inhibitory cytokine-1 (MIC-1) in gastric cancers

Authors 

Kyoung Eun BaekSuk Ran YoonJong-Tae KimK S KimS H KangY YangJ S LimIn Pyo ChoiM S NamM YoonHee Gu Lee

Publisher 

Elsevier

Issue Date 

2009

Citation 

Clinica Chimica Acta, vol. 401, no. 1, pp. 128-133

Keywords 

gastric cancerGDF-15growth differentiation factor-15macrophage-inhibitory cytokine-1MIC-1growth differentiation factor 15cancer cell culturecancer growthcancer tissueprotein secretion

Abstract 

Background: Macrophage inhibitory cytokine-1 (MIC-1), a distant member of the transforming growth factor (TGF)-β superfamily, has been reported to be upregulated and secreted from several cancers. We examined MIC-1 expression and secretion in gastric cancers. Methods: MIC-1 mRNA and protein levels in cancer tissues and cell lines were analyzed by RT-PCR and Western blot. MIC-1 expression in cancer tissues and its secretion in serum were analyzed using immunohistochemistry and ELISA. Results: MIC-1 was significantly upregulated in gastric cancer tissues and cell lines. MIC-1 was secreted from gastric SNU620 cells and its levels in the serum of cancer patients were 10-fold higher than those of healthy controls. In addition, the staining of MIC-1 expression was strongly increased in metastatic gastric cancers. Conclusions: MIC-1 was obviously overexpressed in gastric cancers and MIC-1 secretion into blood may be useful for the prediction of gastric cancer progression.

ISSN 

0009-8981

Link 

http://dx.doi.org/10.1016/j.cca.2008.12.008

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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