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Title 

Naturally acquired IgM antibody response to the C-terminal region of the merozoite surface protein 1 of Plasmodium vivax in Korea: Use for serodiagnosis of vivax malaria

Authors 

J S YeomE S KimK J LimJ H OhMi Jin SohnS B YooE KimI BaeY J JungJ W Park

Publisher 

Journal of Parasitology

Issue Date 

2008

Citation 

Journal of Parasitology, vol. 94, no. 6, pp. 1410-1414

Keywords 

antibodyimmune responsemalariaproteinantibodies, protozoancase-control studiesKoreamalaria, vivaxmass screeningmerozoite surface protein 1

Abstract 

The antibody levels against the C-terminal region of the merozoite surface protein 1 of Plasmodium vivax (PvMSP1c) were measured in 276 patients with P. vivax malaria (patient group), 320 malaria-na?ve healthy individuals (control group 1), and 70 malaria-na?ve individuals with various disorders (control group 2) using the immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA) and the direct sandwich ELISA. To evaluate the antibody response during relapse, 5 relapsed patients were tested using the IgM capture ELISA. The IgM antibodies were negative in 99.7% of control group 1 and in 100% of control group 2; they were positive in 90.6% of the patient group. The total antibody levels were positive in 88.4% of the patient group with the direct sandwich ELISA. The sera from the second malaria episode, i.e., relapsed patients, were 100% positive on the IgM capture ELISA. The results of this study suggest that the IgM capture ELISA may be a useful diagnostic method for P. vivax malaria for both primary infection and relapse.

ISSN 

0022-3395

Link 

http://dx.doi.org/10.1645/GE-1484.1

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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