상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Identification and molecular characterization of PERV gamma1 long terminal repeats

 

PERV gamma1 LTR의 동정과 분자적인 특성 규명

Authors 

Jae Won HuhDae Soo KimH S HaK AhnKyu Tae ChangB W ChoH S Kim

Publisher 

Springer Verlag (Germany)

Issue Date 

2009

Citation 

Molecules and Cells, vol. 27, no. 1, pp. 119-123

Keywords 

long terminal repeatmolecular evolutionmolecular geneticsevolution, molecularmolecular sequence dataterminal repeat sequences

Abstract 

Porcine endogenous retroviruses (PERVs) gamma1 in the pig genome have the potential to act as harmful factors in xenotransplantation (pig-to-human). Long terminal repeats (LTRs) are known to be strong promoter elements that could control the transcription activity of PERV elements and the adjacent functional genes. To investigate the transcribed PERV gamma1 LTR elements in pig tissues, bioin-formatic and experimental approaches were conducted. Using RT-PCR amplification and sequencing approaches, 69 different transcribed LTR elements were identified. And 69 LTR elements could be divided into six groups (15 subgroups) by internal variation including tandem repeated sequences, insertion and deletion (INDEL). Remarkably, all internal variations were indentified in U3 region of LTR elements. Taken together, the identification and characterization of various PERV LTR transcripts allow us to extend our knowledge of PERV and its transcriptional study.

ISSN 

1016-8478

Link 

http://dx.doi.org/10.1007/s10059-009-0013-3

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)